Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis.
Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness.We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2.In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice agains